Careflow® is a patented, organic and standardised mango fruit powder. Careflow® activates the key metabolic enzymes SIRT1 and eNOS, to improve microcirculation and vascular function. Supported with one acute and one chronic published clinical trial. 100 mg/day.

Careflow® - Key features

  • Patented ingredient
  • Reinforces the activation of SIRT1 for cellular metabolism
  • Boosts the endothelial nitric oxide synthase (eNOS)
  • Improves microcirculation significantly from the first intake
  • Significantly enhances the vascular function after a month of supplementation
  • Protects the homeostasis of the metabolism

Science supporting Careflow®

Careflow® improves microcirculation. Its mechanism of action in SIRT1 modulation and eNOS activation has been analysed in in-vitro studies. Its benefits have been confirmed in acute and in chronic gold-standard clinical studies.


Careflow® is a standardised whole fruit powder of mango Mangifera indica L. obtained from the subspecies Totapuri (a.k.a. Kili-Mooku). It is cultivated in the Tamil Nadu region of India, at a specific degree of maturity, when the content of secondary plant compounds is high.

Bioactive compounds
  Mangiferin                 ≥ 0.03%

Composition: Mango fruit powder (Mangifera indica (L.) spp. Totapuri)

Recommended daily dosage: 100 mg/day

Mechanism of action

Careflow® activates SIRT1.  

Sirtuin 1 (SIRT1) is a master switch enzyme for energy homeostasis and cellular metabolism. It protects and enhances cell life by increasing mitochondrial metabolism, thermogenesis and antioxidant protection.


Careflow® stimulates Endothelial Nitric Oxide Synthase (eNOS).

Endothelial NOS is an enzyme that produces nitric oxide (NO), which facilitates vasodilation and anti-inflammatory processes.

Digested Careflow® showed a significant activation of eNOS, in a dose-dependent pattern. 

Careflow® provides antioxidant and anti-inflammatory effects.

  • Careflow® stimulates SOD (superoxide dismutase) by more than 45%.
  • Careflow® has anti-inflammatory effect by inhibition of IL-6, TNF-alpha release and COX 1 / 2 activity.

Clinically supported benefits

Double-blind, randomised, placebo-controlled studies.


BioTeSys GmbH, Germany

BioTeSys GmbH, Germany



4 weeks


10 subjects
BMI 19-30 kg/m2
Age: 43-70 years old

75 subjects
Women and men
BMI 19-30 kg/m2
Age: 40-70 years old


Blood flow & oxygen circulation
O2C (Oxygen-to-see)
Combines laser doppler & tissue spectroscopy

O2C + Reactive hyperemia flow (RH-flow)


100 mg/day of Careflow in water 

100 mg/day of Careflow in water 

Careflow® improves microcirculation after the first dose.

The relative blood flow is a key parameter for microcirculation in acute studies.

The blood flow was significantly improved with Careflow® compared to baseline. Maximal effects were reached after 6 hours.

Blood flow increased significantly by 54% above the baseline with 100mg of Careflow®.

Careflow® improves vascular function after a month of supplementation.

The reactive hyperemia flow (RH-flow) is an important parameter for microcirculation in long-term studies.

The RH-flow and the responsiveness of the microvascular system are significantly improved after 4 weeks of supplementation with 100mg of Careflow®.

Careflow® is safe.

No adverse event linked to Careflow® supplementation has been recorded.

Regulatory & Certifications

Organic certified
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians


Röchter S. et al. Agro Food Industry Hi-Tech. 2015; Vol. 26(3)
Gerstgrasser A. et al. Planta Med. 2015; 82(4), 298-304

Buchwald-Werner S. et al. Planta Med. 2017; 83(10): 824-829
Gerstgrasser A. et al. Planta Med. 2015; 82(4), 298-304

This website is intended to provide information about Fytexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public.  Statements used on this website have not been evaluated by the Food and Drug Administration or any other competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.