Benegut® is a patented botanical extract from shiso leaves (Perilla frutescens) combining antispasmodic effect and action on tight junction leakage to reduce the root causes of functional dyspepsia. Benegut® is clinically proven to contribute to a significant reduction of intestinal discomfort. Supported with an acute and a chronic clinical trial. 300 mg/day.
Benegut® - Key features
Contributes to the reinforcement of tight junctions of cells
Provides an antispasmodic effect
Clinically proven to rapidly reduce overall gastrointestinal discomfort
Improves bloating, feeling of fullness and abdominal comfort
Science supporting Benegut®
Benegut® is targeting digestive comfort and functional dyspepsia symptoms. Its mechanism of action on exploring antispasmodic effects and preventive effects on tight junction leakage, some of the causes of functional dyspepsia, have been studied in-vivo and in-vitro. The clinical benefits of Benegut® have been demonstrated in a chronic and an acute gold-standard clinical studies.
Benegut® is a patented botanical extract obtained by water extraction of shiso leaves (Perilla frutescens L.), an annual edible herbaceous plant harvested on the island of Hokkaido in Japan. Benegut® is standardised on a special flavonoid fraction and its key active ingredient Vicenin 2 and on rosmarinic acid, determined by HPLC.
Rosmarinic acid ≥ 0.05%
Special flavonoids fraction ≥ 0.18%
incl. Vicenin-2 ≥ 0.007%
Composition: Shiso leaf extract (Perilla Frutescens L.)
Recommended daily dosage: 300 mg
Mechanism of action
Benegut® contributes to the reinforcement of tight junctions of cells.
The effect of Benegut® on TNFα-caused tight junction leakage was investigated on intestinal epithelial cells (Caco-2).
Benegut® showed a significant restorative effect on the tight junctions, after 6 hours until 24h against TNF-α treatment.
Benegut® shows anti-spasmodic effects.
Benegut® and isolated Vicenin-2 significantly decreased acetylcholine- or Ba2+ -induced rat ileum contractions, indicating an antispasmodic effect.
Clinically supported benefits
Benegut® helps to significantly improve GI symptoms over time.
Double-blind, randomised, placebo-controlled study.
|YEAR & DURATION
Baseline – Run-in Phase (2 weeks)
Confounding factors monitored: Perceived stress PSQ20 score; stool frequency
After 4 weeks, all criteria for digestive comfort have been significantly improved following the consumption of Benegut®:
- Lowered bloating
- Reduced passage of gas
- Reduced gastrointestinal rumbling
- Improved feeling of fullness
- Reduced overall abdominal discomfort
Benegut® improves digestive comfort after the first intake.
Acute, double-blind, randomised, powered cross-over study.
|YEAR & DURATION
Acute - Over 90min
Gastrointestinal symptoms after a high caloric meal
ORODISPERSIBLE STICK PACKS
Benegut® consumption helped to significantly reduce overall gastrointestinal discomfort 90 mins after the consumption of a high caloric meal.
Feeling of fullness, bloating and burping are the three main symptoms driving the improvement in gastrointestinal discomfort.
Benegut® is safe.
No adverse event linked to Benegut® supplementation has been recorded.
Regulatory & Certifications
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians
2023 Publication pending
Buchwald-Werner S. et al. BMC Complement Altern Med. 2014; 14:173
Verspohl J. et al. Phytomedicine. 2013; 427–431
Buchwald-Werner S. et al. Agro Food Industry Hi Tech. 2016; vol. 27(5)
WO2013079623. Vicenin 2 and derivatives thereof for use as antispasmodic and/or prokinetic agent.
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