Stress relief for cognitive performance
Bluenesse® is a patented lemon balm extract (Melissa officinalis), standardised at 6% rosmarinic acid, with demonstrated muscarinic M1 receptor affinity. Bluenesse® balances cortisol levels within 1 hour, supporting stress relief and acute nootropic effect for cognitive performance. Supported by published clinical trials. 300mg/day.
Bluenesse® - Key features
- Rapidly impacts cortisol levels
- Reduces anxiety
- Provides nootropic effect
- Helps to manage stress level for a better cognitive performance
Science supporting Bluenesse®
Bluenesse® provides an immediate improvement in stress relief and cognitive performance. Its mechanism of action in affinity to the muscarinic M1 receptor, has been analysed in in vitro studies. Its benefits have been confirmed in two published acute clinical studies on young population.
Bluenesse® is a botanical extract obtained by water extraction of lemon balm leaves (Melissa officinalis L.), a traditional herb native to and cultivated in Europe. Specific batches of lemon balm are selected for their capacity to bind to the muscarinic M1 receptor. Bluenesse® is standardised to 6% rosmarinic acid.
Primary active compounds
Rosmarinic acid ≥6%
Muscarinic M1 receptor activity ✓
Composition: Lemon balm water extract (Melissa officinalis L.)
Recommended daily dosage: 300 mg
Mechanism of action
Bluenesse® has affinity to muscarinic M1 receptor.
Muscarinic receptors, as part of the cholinergic system, have been reported to play a key role for cognitive effects, including alertness and memory.
The experiments demonstrated significant muscarinic M1 receptor binding properties of Bluenesse®.
600 mg of Bluenesse® + natural sweeteners
Rosmarinic acid is a known GABA transaminase and acetylcholine esterase inhibitor.
- Higher concentrations of GABA are support a calm mood.
- Elevated acetylcholine levels are improving memory and cognition.
Bluenesse® consumption induces a statistically significant increase in rosmarinic acid blood concentration from 0.5 to 2 h, compared to baseline levels.
Clinically supported benefits
Randomised, placebo-controlled, cross-over studies.
No caffeine, Light meal
No caffeine, Light meal
ICED DRINK 480 ml/day
YOGHURT 250 g/day
Bluenesse® reduces cortisol levels and anxiety.
Bluenesse® is clinically proven to reduce cortisol levels and therefore limits the negative impact of stress.
Bluenesse® provides a nootropic effect.
Bluenesse significantly improved working memory, alertness, math performance and immediate word recall at both 1 hour and 3 hours after supplementation.
Regulatory & Certifications
No allergens, non-GMO, Kosher, Halal, gluten-free, suitable for vegetarians
Buchwald-Werner S. et al. Agro Food Industry Hi Tech. 2015; vol 26 (1)
Scholey A. et al. Nutrients. 2014; 6, 4805-4821
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