Immune & respiratory health
Promunel® is the first characterised and scientifically supported propolis extract, obtained from the patented Multi Dynamic Extraction (M.E.D.TM) process. Promunel® contributes to support immune and respiratory health. Proven by a clinical study confirming its efficacy for the comfort of the throat and upper respiratory tract.
Promunel® – key features
Characterised and standardised polyphenolic pattern
Obtained with the patented M.E.D.™ process which preserves the complete polyphenolic complex as occuring naturally in raw propolis
Regulates the local and systemic anti-inflammatory response
Demonstrated antibacterial efficacy
Clinically proven to improve the comfort of upper respiratory tract within 3 days of supplementation
Science supporting Promunel®
It has taken many years to develop Promunel®, transforming raw propolis into an advanced ingredient. Traditionally propolis has a complex composition and natural variability but this research has enabled us to produce a characterised and standardised propolis extract. The mechanism of action and clinical benefits of Promunel® have been demonstrated in a study of 122 subjects suffering from upper respiratory tract discomfort.
Process & characterisation
More than 300 polyphenols have been identified in propolis and its bioactive composition is also highly variable depending on geographic area, climatic conditions, plant species and seasonality.
Over the past decade, Fytexia has developed the Multi Dynamic Extraction (M.E.D.TM) process to extract a wide polyphenolic spectrum and obtain a wide reproducible fingerprint of characteristic polyphenols.
The M.E.D.TM process used to produce Promunel® allows the extraction of the complete, intact and identified polyphenolic complex. It ensures that at least 25% of the polyphenols in Promunel® are represented by the six main flavonoids of propolis: Galangin, Quercetin, Pinocembrin, Pinobanksin, Apigenin, Chrysin.
Six main flavonoids of propolis in Promunel®
Galangin, Quercetin, Pinocembrin, Pinobanksin, Apigenin, Chrysin
≥25% of the total polyphenols content in HPLC-ESI-MS
To enable application in a range of delivery systems, Promunel® is available in four different formats, each with the same the HPLC-UV profile, guaranteeing the bioactive polyphenols in all of them.
|EPE 38 80 GA
38 mg/ml total polyphenols expressed as Galangin
UV Folin Ciocaleu HPLC-ESI-MS
|RECOMMENDED DAILY DOSE
Clinically supported benefits
Double-blind, randomised, placebo-controlled study.
Samnium Medical Cooperative
|YEAR & DURATION
5 days of supplementation and follow-up
T0=baseline; T1=after 3 days; T2=after 5 days
Follow-up: T3-15 days after the end of supplementation
Age: 18-77 years old
Inclusion with mild upper respiratory tract discomfort
|Clinical evaluation by medical doctor for upper respiratory tract discomfort
Throat swabs for bacterial collection
|Propolis oral spray
2-4 sprays three times/day over 5 days
Equivalent to 12-14 mg of standardised polyphenols per day
Promunel® improves upper respiratory tract comfort within 3 days of supplementation.
- After 3 days of supplementation, 83% of the subjects taking Promunel® oral spray experienced an improvement of upper respiratory tract comfort, against 28% in the placebo group.
After 5 days, all the subjects experienced a reduction in respiratory discomfort.
Mild upper respiratory tract discomfort cleared up two days earlier in the supplemented group.
Promunel® is safe
No adverse event linked to Promunel® supplementation has been recorded.
Regulatory & Certifications
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians
Available as organic
Zaccaria et. al. Materials, 2019
Zaccaria et. al. Nutrients, 2017
Garzarella et al. Biomedecine & Pharmacotherapy, 2022
Curti et al. International journal of molecular sciences, 2019
Esposito et al. Phytomedicine, 2020
This website is intended to provide information about Fytexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by the Food and Drug Administration or any other competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.