Joint comfort in motion
FWRD® is a mangosteen peel extract standardised in xanthones, designed to support healthy joint comfort and cartilage protection. Supported with a mechanistic study and a clinical trial. 200 mg/day.
FWRD® - Key features
- Mangosteen extract standardised in α + ɣ mangostins
- Fruit pericarp extract, a co-product of mangosteen juice manufacturing
- Complete characterisation of polyphenols & metabolites
- Clinically proven to promote healthy joint comfort
- Significant improvements in knee stiffness and functionality after 2 weeks
- Supports the modulation of cartilage degradation factors
Science supporting FWRD®
FWRD® supports healthy joint comfort and cartilage protection. Its mechanism of action is supported by an ex vivo study demonstrating that FWRD® may prevent cartilage degradation and inflammation, which may be contributing to improved joint stiffness and enhanced joint function. Its clinical benefits are highlighted through a randomised, double-blind, multi-arm, parallel and placebo-controlled study, proving significant improvements in joint discomfort, knee stiffness and functionality.
Characterisation
FWRD® is a mangosteen peel extract standardised in xanthones. Sourced from Thailand or Malaysia, FWRD® is derived from the fruit pericarp, a co-product of the agro-industry, ensuring maximum raw material valorization.
Bioactive compounds
Total Xanthones 37-48%
α + ɣ mangostins 29-41%
Composition: Mangosteen peel extract (Garcinia mangostana L.) - carrier-free
Recommended daily dosage: 200 mg
Mechanism of action
An ex vivo study conducted on blood collected from participants in the clinical trial confirms the mode of action of FWRD®, with a reduction of inflammation biomarkers, NO and PGE2, and catabolic biomarkers, MMP13 collagenase.
FWRD® prevents inflammation.
FWRD® reduces levels of NO and PGE2, markers of cartilage inflammation, indicating prevention of inflammatory processes.
FWRD® prevents cartilage degradation.
FWRD® prevents the increase of collagenase MMP13, a catabolic marker, suggesting protection against cartilage degradation.
By preventing cartilage degradation, FWRD® may be contributing to improved joint stiffness and enhanced function.
Clinically supported benefits
Randomised, double-blind, multi-arm, parallel and placebo-controlled study.
| LOCATION |
Murcia, Spain |
| YEAR & DURATION | 2023 12 weeks of supplementation |
| POPULATION |
25 subjects per arm
|
| PROTOCOL |
Outcomes |
| INTAKES |
CAPSULE |
FWRD® has been demonstrated to significantly reduce joint discomfort from 28 days of supplementation, with notable improvements in knee stiffness and functionality.
Significant improvement after 28 days on the total score for the supplemented group: joint discomfort is reduced by 46% after 28 days vs baseline.
Stiffness and functional subscales reflect how daily activities are impacted by disability.
After 16 days of supplementation:
- Joint stiffness is reduced by 46% vs baseline.
- Joint functionality is improved by 37% vs baseline.
FWRD® is ideal for integration into capsules, tablets, and sachets, empowering brands to deliver targeted support for active lifestyles and healthy ageing.
FWRD® is safe
No adverse event linked to FWRD® supplementation has been recorded.
12-week FWRD® supplementation does not affect biological & physiological safety parameters.
Regulatory & Certifications
Non-GMO, Halal, gluten-free, suitable for vegetarians.
New Dietary Ingredient (NDI) - NDIN accepted by FDA
References
CLINICAL TRIALS
Romain C. & Cases J.; Agro Food Industry Hi Tech; 2015, 26(3):8-13
New study publication pending
This website is intended to provide information about Fytexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by the Food and Drug Administration or any other competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.
