Managing Histamine Intolerance with adiDAO®: Science-Backed DAO Supplementation

16/12/2025

Histamine intolerance is emerging as a significant driver of digestive discomfort, headaches and other health issues beyond the digestive tract in today’s health-conscious consumers.

WHY FOCUS ON DAO?

Diamine oxidase (DAO) is a functional enzyme that breaks down histamine from diet. Under normal conditions, food-derived histamine is metabolised by DAO in the small intestine. However, when DAO activity is reduced, histamine from food is not efficiently degraded. This imbalance, known as histamine intolerance, leads to excessive activation of histamine receptors causing a wide range of clinical manifestations.

  • DAO activity is influenced by genetics, gut disorders, diet, and certain medications.
  • 66% of the population may have a genetic predisposition to DAO deficiency.
  • 79% of individuals with clinical manifestations of histamine intolerance carry genetic variants reducing DAO activity.
  • Up to 88% of individuals with histamine intolerance report digestive discomfort.

 

This highlights the importance of nutritional strategies that help maintain histamine balance, creating opportunities for innovative ingredient solutions such as DAO supplementation.

 

DOWNLOAD THE ADIDAO BROCHURE

 

GASTROINTESTINAL DISORDERS MODULATION

Randomised, double blinded, single-center, single ascending dose (SAD) study.

  • 10 healthy  subjects experiencing histamine intolerance
  • 4 phases of 2 weeks each with increasing doses of adiDAO®Veg
  • 3 tablets a day of adiDAO veg (4.2 mg to 33.6 mg) or placebo
  • Self-reported symptoms

Phase 1 - 4.2 mg of adiDAO®Veg 
- Reduced bloating, improved bowel regularity, less abdominal swelling

- Fewer headaches

- Reduced skin lesions

Phase 2 - 8.4 mg of adiDAO®Veg
- Reduced digestive discomfort

- Fewer headaches

- Reduced rhinorrhea

Phase 3 - 16.8 mg of adiDAO®Veg
- Overall improvement in gastrointestinal symptoms, less bloating

- Reduced rhinorrhea and nasal congestion

Phase 4 - 33.6 mg of adiDAO®Veg
- Less post-meal swelling, improved gastrointestinal complaints

- Reduced fatigue and chronic pain
- Improved skin and respiratory symptoms

 

access ADIDAO SCIENTIFIC DATA

Semi-Finished & Finished Formats for Custom Developments

Powered by adiDAO®, these formats are designed for gastro-resistant performance, stability, and compatibility, forming the foundation for a wide range of digestive and histamine-regulating applications.
Accelerate your development pipeline with our ready-to-integrate delivery systems:

  • adiDAO® Tablets: Gastro-resistant tablets containing the DAO enzyme. 
  • EFICAPS adiDAO® capsules - Vitamin C & Quercetin: Gastro-resistant tablets with controlled-release of DAO in the intestine and immediate-release of complementary active ingredients such as vitamin C and quercetin. 
  • EFICAPS adiDAO® capsules – Caffeine & B Vitamins: Combines DAO enzyme with caffeine, folic acid, vitamin B6, and vitamin B12 , which act as complementary ingredients to promote optimised function.



Contact Us to Discuss your Formulation Needs

This website is intended to provide information about Fytexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public.  Statements used on this website have not been evaluated by the Food and Drug Administration or any other competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.