Immune & respiratory health
Promunel® is a brown propolis extract obtained from the patented Multi Dynamic Extraction process, guaranteeing a characterised and standardised full spectrum of polyphenols. Promunel® contributes to support immune and respiratory health. Promunel® is clinically proven to improve the comfort of the upper respiratory tract within 3 days.
Promunel® – key features
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Brown propolis extract, obtained with the patented M.E.D.™ process which preserves the complete polyphenolic complex as occuring naturally in raw propolis
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Demonstrated immunomodulatory role through macrophage polarisation - Published patent application
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Clinically proven on 295 subjects to reduce the incidence of upper respiratory discomforts and shorten the average number of days with discomforts.
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Clinically proven on 122 subjects to reduces the discomfort of upper respiratory tract within 3 days of supplementation
Science supporting Promunel®
It has taken many years to develop Promunel®, transforming raw propolis into an advanced ingredient. Traditionally propolis has a complex composition and natural variability but this research has enabled us to produce a characterised and standardised propolis extract. The mechanism of action and clinical benefits of Promunel® have been demonstrated in a study of 122 subjects suffering from upper respiratory tract discomfort.
Mechanism of action
A complete characterisation of the bioactive polyphenols of Promunel has been complited: 96% of the propolis polyphenol fingerprint is identified.
The immunomodulatory role of Promunel through macrophage polarisation has been demonstrated and a patent application has been published.
Promunel enhances the body’s innate immune system readiness:
Promunel supports the reprogramming of M2c macrophages from immunosuppressive state towards a functional M1-like phenotype.
Promunel actively primes the innate immune system, while supporting a controlled and balanced inflammatory response. The synergistic activity of its phenolic compounds plays a critical role in optimising this immunological priming.
Process & characterisation
More than 300 polyphenols have been identified in propolis and its bioactive composition is also highly variable depending on geographic area, climatic conditions, plant species and seasonality.
Over the past decade, Fytexia has developed the Multi Dynamic Extraction (M.E.D.TM) process to extract a wide polyphenolic spectrum and obtain a wide reproducible fingerprint of characteristic polyphenols.
The M.E.D.TM process used to produce Promunel® allows the extraction of the complete, intact and identified polyphenolic complex. It ensures that at least 25% of the polyphenols in Promunel® are represented by the six main flavonoids of propolis: Galangin, Quercetin, Pinocembrin, Pinobanksin, Apigenin, Chrysin.
Six main flavonoids of propolis in Promunel®
Galangin, Quercetin, Pinocembrin, Pinobanksin, Apigenin, Chrysin
≥25% of the total polyphenols content in HPLC-ESI-MS
To enable application in a range of delivery systems, Promunel® is available in four different formats, each with the same the HPLC-UV profile, guaranteeing the bioactive polyphenols in all of them.
| COMMERCIAL NAME |
ESIT® |
GREIT®
|
EPE® Hydroalcoholic extract |
POLE®
|
| GRADE |
ESIT 12 |
GREIT 120
|
EPE 38 80 GA 38 mg/ml total polyphenols expressed as Galangin UV Folin Ciocaleu HPLC-ESI-MS |
POLE G
|
| RECOMMENDED DAILY DOSE | 100-200 mg | 1-2 ml | 0.31-0.62 ml | 0.4-0.8 ml |
| DELIVERY SYSTEMS | Tablets Capsules |
Spray |
Tinctures | Soft gels Gummies |
Clinically supported benefits
Double-blind, randomised, placebo-controlled study.
| LOCATIONS | Murcia, Spain UCAM, University of Murcia |
| YEAR & DURATION | 2022-2024 12 weeks of supplementation Automn to Spring period |
| POPULATION | 295 subjects Age: 25-69 years old BMI: 18.5-29.9 kg/m2 |
| PROTOCOLS | Upper respiratory tract infections Risk, incidence, occurrence Wisconsin Upper Respiratory Symptom Survey (WURSS24) completed daily on an app |
| INTAKES | CAPSULES 2 x 200 mg / day (one at breakfast and one at dinner) 48 mg of polyphenols |
Promunel® reduces the incidence of upper respiratory discomfort events by 29%.
Promunel® helps lower the risk of experiencing upper respiratory discomforts.
Promunel® supplementation significantly reduces the risk of experiencing respiratory discomforts by 31%.
Promunel® contributes to shorten the average days experiencing upper respiratory discomforts.
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Double-blind, randomised, placebo-controlled study.
| LOCATIONS | Benevento, Italy Samnium Medical Cooperative |
| YEAR & DURATION | 2020 5 days of supplementation and follow-up T0=baseline; T1=after 3 days; T2=after 5 days Follow-up: T3-15 days after the end of supplementation |
| POPULATION | 122 subjects Age: 18-77 years old Inclusion with mild upper respiratory tract discomfort |
| PROTOCOLS | Clinical evaluation by medical doctor for upper respiratory tract discomfort Throat swabs for bacterial collection Questionnaires |
| INTAKES | Propolis oral spray 2-4 sprays three times/day over 5 days Equivalent to 12-14 mg of standardised polyphenols per day |
Promunel® improves upper respiratory tract comfort within 3 days of supplementation.
- After 3 days of supplementation, 83% of the subjects taking Promunel® oral spray experienced an improvement of upper respiratory tract comfort, against 28% in the placebo group.
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After 5 days, all the subjects experienced a reduction in respiratory discomfort.
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Mild upper respiratory tract discomfort cleared up two days earlier in the supplemented group.
Promunel® is safe
No adverse event linked to Promunel® supplementation has been recorded.
Regulatory & Certifications
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians
Available as organic
References
PROCESS
Zaccaria et. al. Materials, 2019
MECHANISTIC STUDIES
Zaccaria et. al. Nutrients, 2017
Garzarella et al. Biomedecine & Pharmacotherapy, 2022
CLINICAL TRIALS
Esposito et al. Phytomedicine, 2020
This website is intended to provide information about Fytexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by the Food and Drug Administration or any other competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.
