Sleep & mental fatigue
SAC-1 is a fermented garlic extract that helps to regulate the parasympathetic nervous system to trigger the body's rest and restor system. Clinically proven to improve sleep & mental fatigue. Supported with published clinical trials. 200 mg/day.
SAC-1™ - Key features
- Fermented garlic extract standardised at 1% S-Allyl Cysteine (SAC)
- Obtained from the patented Saclation® process
- Clinically proven to significantly improve sleep quality
- Contributes to reduce mental and physical fatigue
Science supporting SAC-1™
SAC-1 is protected by patents covering its manufacturing process, which ensures a high concentration in S-Allyl Cysteine (SAC), an organosulfur compound derived from the amino acid cysteine. Its impact on sleep and mental fatigue have been demonstrated in several clinical studies, which also confirm the mechanism of action on the regulation of the autonomic nervous system.
Characterisation
Primary active compound
S-allyl Cysteine (SAC) > 1%
Sulfur compound derived from amino acid cysteine
Composition: Garlic extract (Allium Sativum L.)
Recommended daily dosage: SAC-1TM - 200 mg
Mechanism of action
SAC-1 aims to promote the parasympathetic "rest-and-digest" nervous system, helping to calm down the metabolism and maintain homeostasis when the body is at rest, for a better sleep at night.
Clinically supported benefits
Randomised, placebo-controlled studies
| YEAR & DURATION | 2024 12 weeks |
2018 |
| POPULATIONS |
41 subjects 20 men & 21 womenAge: 45±3.0 years old |
29 subjects 12 men & 17 women |
| PROTOCOLS |
Sleep evaluation Pittsburgh Sleep Quality Index (PSQI) OSA-MA, upon waking up at baseline (W0) and endpoint (W12) in three consecutive days |
Sleep evaluation OSA-MA upon waking up Visual Analog Scale upon waking up |
| INTAKES | TABLETS 200 mg/day |
FOOD 140 mg/day |
SAC-1™ improves sleep quality
A 200mg daily supplementation of SAC-1™ contributes to improving overall sleep score, driven by enhancements in sleep quality and latency.
SAC-1™ contributes to reduce mental fatigue.
A randomized, double-blind, placebo-controlled, parallel design on 20 health subjects has been performed to determine the feeling of fatigue in everday life, after a mental load (Cognitrax). After 4 weeks of supplementation, the fatigue score is significantly decreased, with an improvement of more than 10 points of the scale, signing perceptible clinical improvement in reducing mental fatigue.
After a mental load, SAC-1 significantly reduced fatigue score of supplemented subjects.
SAC-1™ contributes to reduce physical fatigue.
An aditionnal clinical study performed on 20 healthy subjects over 4 weeks, demonstrated that the feeling of fatigue after exercise reduced significantly with SAC-1.
SAC-1™ is safe.
No adverse event linked to SAC-1™ supplementation over the period 2008-2023 has been recorded.
Regulatory & Certifications
Non-GMO, Halal, gluten-free, suitable for vegans
FOOD WITH FUNCTION CLAIMS (FFC) IN JAPAN
1.S-allyl cysteine (SAC) has been reported to reduce temporary mental fatigue caused by tasks that require attention and thinking.*
2. S-allyl cysteine (SAC) has also been reported to reduce temporary physical fatigue caused by daily activities.*
References
CLINICAL TRIALS
2019; Japanese Pharmacology and Therapeutics 47(3):527-536
2019; Japanese Pharmacology and Therapeutics（薬理と治療) vol.47 no.4
2021; Japanese Pharmacology and Therapeutics（薬理と治療) vol.49 no.12
2025; Functional Foods in Health and Disease vol.15 no.1
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